Using molecular biology, hormone levels and responses and other clinical diagnostic studies, aspects of pathophysiology of abnormal sexual differentiation are being defined. The new emphasis is upon genetic mutations and inhibin B levels in disorders of male differentiation, particularily cryptorchidism among infants and pubertal aged males.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
Kelsey, Megan M; Braffett, Barbara H; Geffner, Mitchell E et al. (2018) Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab 103:2309-2318
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Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
Sereika, Susan M; Becker, Dorothy; Schmitt, Patricia et al. (2016) Operationalizing and Examining Family Planning Vigilance in Adult Women With Type 1 Diabetes. Diabetes Care 39:2197-2203
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