Even though polycystic ovarian syndrome (PCOS) and/or hperandrogenism, insulin resistance acanthosis nigricans (HAIR/AN) is extensively studied in adult women, the pediatric literature remains deficient. The manifestations of the syndrome in the premenarchal and/or peripubertal female remains poorly described, if at all. Moreover, the pathophysiology of hyperinsulinemia remains uncertain. It is not known if hyperinsulinemia is a compensatory mechanism secondary to insulin resistance, or if it is an early and primary abnormality of pancreatic B-cell hypersecretion. Therefore, the aims of this proposal are: 1) to characterize the metabolic profile of children HAIR-AN/PCOS by investigating the balance between insulin secretion and action. To assess the effects of Metformin treatment in adolescents with PCOS and imparied glucose tolerance on insulin sensitivity and hyperandrogenemia.
Showing the most recent 10 out of 364 publications