Even though polycystic ovarian syndrome (PCOS) and/or hperandrogenism, insulin resistance acanthosis nigricans (HAIR/AN) is extensively studied in adult women, the pediatric literature remains deficient. The manifestations of the syndrome in the premenarchal and/or peripubertal female remains poorly described, if at all. Moreover, the pathophysiology of hyperinsulinemia remains uncertain. It is not known if hyperinsulinemia is a compensatory mechanism secondary to insulin resistance, or if it is an early and primary abnormality of pancreatic B-cell hypersecretion. Therefore, the aims of this proposal are: 1) to characterize the metabolic profile of children HAIR-AN/PCOS by investigating the balance between insulin secretion and action. To assess the effects of Metformin treatment in adolescents with PCOS and imparied glucose tolerance on insulin sensitivity and hyperandrogenemia.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
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Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
Leslie, Elizabeth J; Liu, Huan; Carlson, Jenna C et al. (2016) A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet 98:744-54
Kelsey, Megan M; Geffner, Mitchell E; Guandalini, Cynthia et al. (2016) Presentation and effectiveness of early treatment of type 2 diabetes in youth: lessons from the TODAY study. Pediatr Diabetes 17:212-21

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