This study has 3 major aims which are all designed to understand the mechanism that causes cognitive deterioration during mild hypoglycemia in children with IDDM and to assess a possible therapeutic strategy to prevent this cognitive deterioration. This study is also designed to verify the experimental insulin glucose clamp paradigm used to assess responses to hypoglycemia. The study will measure mental efficiency before, during and after an episode of mild and slightly more severe hypoglycemia of different durations. Counterregulatory hormones will be measured and blood will be drawn for measurement of glucose transporters on the red blood cells. In addition, estimations of """"""""mental reserve"""""""" with a comprehensive neuropsychological test battery will be performed prior to the insulin glucose clamp. Assessment will be made of possible central neuropathy using auditory brain stem evoked potential. Lactate measures will be made during the induced hypoglycemia nad in Aim 2 the efficency of intravenous lactate in preventing hypoglycemia associated cognitive dysfunction will be evaluated.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000084-38
Application #
6408083
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1974-10-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
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Kriska, Andrea; El Ghormli, Laure; Copeland, Kenneth C et al. (2018) Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes 19:36-44
Venditti, E M; Tan, K; Chang, N et al. (2018) Barriers and strategies for oral medication adherence among children and adolescents with Type 2 diabetes. Diabetes Res Clin Pract 139:24-31
Gidding, Samuel S; Bacha, Fida; Bjornstad, Petter et al. (2018) Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr 192:86-92.e5
Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
Leslie, Elizabeth J; Liu, Huan; Carlson, Jenna C et al. (2016) A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet 98:744-54
Kelsey, Megan M; Geffner, Mitchell E; Guandalini, Cynthia et al. (2016) Presentation and effectiveness of early treatment of type 2 diabetes in youth: lessons from the TODAY study. Pediatr Diabetes 17:212-21

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