EXCEED THE SPACEPROVIDED.The Children's Hospital GCRC is centrally located to provide inpatient and outpatient research facilities andsupport for patient-oriented investigations. It serves investigators at the academic institutions and thehospitals of the University of Pittsburgh Medical Center Health Systems to conduct research related todisorders of infancy, childhood, adolescence and young adults. This GCRC is a valuable resource for trainingyoung investigators and sponsors formal as well as practical training in research methodologies. Presently,NIH funded clinical investigations in the GCRC cover a wide spectrum of human disorders. These includetype 1 diabetes in children, treatment of severe pediatric obesity and its co-morbidities, racial predispositionto obesity, insulin resistance and type 2 diabetes, effects of middle ear effusion on balance and speechdevelopment, genetics of middle ear disease and congenital adrenal hyperplasia, genetic factors in childhood-onset depression, Group A streptococcal infections in school children, diagnosis of abuse in children,immunosuppression modalities in organ transplantation, treatment of cystic fibrosis, the genetics ofnecrotizing enterocolitis, and last but not least new therapies in traumatic brain injury. The GCRCinvestigators come from a diversity of disciplines including medicine, nursing, dentistry, behavioral sciences,public health and engineering. Since the last competitive renewal the GCRC supported the successfulacquisition of K23 awards by three young GCRC investigators. Moreover, new training opportunities wererealized by the awarding of a K24, T32 and K12 grants to the Program Director and Associate Director. Thepresent application requests support for 5 years (years 43-47) for the pediatric GCRC to continue itsproductivity in clinical research and in training the new generation of scientists in patient-oriented research.
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