Abstract

Examines the acute behavioral, EEG and hormonal changes that occur when humans are exposed to the physiological doses of the hormone at noon, early evening and late evening. This will test the relationship between efficacy of melatonin doses and circadian time. Levels of alertness and psychomotor performance will be continuously assessed. EEG patterns during 2 hour sleep test will be registered and blood samples will be taken via indwelling venous catheter for determination of serum melatonin levels.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000088-32
Application #
3741363
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36
Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9
Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81
Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82
Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9
Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53
Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2004) Does menarche mark a period of elevated resting metabolic rate? Am J Physiol Endocrinol Metab 286:E456-62
Anderson, S E; Bandini, L G; Dietz, W H et al. (2004) Relationship between temperament, nonresting energy expenditure, body composition, and physical activity in girls. Int J Obes Relat Metab Disord 28:300-6

Showing the most recent 10 out of 144 publications