Abstract

In a recent study on the minimum requirement leucine we observed a peculiar pattern in leucine oxidation after three equal """"""""bulk meals"""""""" and an apparent positive balance due to a 24h leucine oxidation 22% lower than the intake. Therefore, we need to investigate whether and, if that is the case, to what extent our tracer model underestimates leucine oxidation in experimental conditions involving bulk meals. We also need to understand if the lower oxidation observed at lunch is due to an increased splanchnic uptake or simply to a larger portion of """"""""first pass"""""""" uptake of leucine which undergoes to oxidative metabolism. To achieve these goals we will perform in each volunteer a series of three 24h tracer infusionsby administering simultaneously D3 and 13C leucine orally and I.V.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000088-34
Application #
6246690
Study Section
Project Start
1997-03-20
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
34
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36
Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9
Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81
Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82
Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9
Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53
Koutkia, Polyxeni; Canavan, Bridget; Breu, Jeff et al. (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287:E506-12
Schurgin, Sunita; Dolan, Sara; Perlstein, Ari et al. (2004) Effects of testosterone administration on growth hormone pulse dynamics in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 89:3290-7

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