Abstract

For this study patients with drug resistant tremor (due to PD or essential tremor) are taken to the operating room. While they are awake, an electrode is placed within the ventrointermediate nucleus of the thalamus. Proper placement of this electrode requires physiologic testing whereby various areas of the thalamus are stimulated and the effects are recorded. Once an area can be found that allows adequate tremor suppression with minimal side effects, a permanent stimulator (much like a pacemaker) is implanted just under the skin just below the patient's clavicle. Once the stimulator is in place, the investigator may adjust stimulation parameters to provide the optimal benefit. Post-op evaluation of these patients includes an elaborate examination of their autonomic function within the CRC. In addition to aiding patients with medication-resistant tremor, this study provides us with information regarding various functional areas of the thalamus. In the near future, further studies are planned involving the stimulation of other areas of the basal ganglia for the treatment of other neurodegenerative diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000095-36
Application #
5219428
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Kaltenbach, Karol; O'Grady, Kevin E; Heil, Sarah H et al. (2018) Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. Drug Alcohol Depend 185:40-49
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Joy, Nino G; Mikeladze, Maia; Younk, Lisa M et al. (2016) Effects of equivalent sympathetic activation during hypoglycemia on endothelial function and pro-atherothrombotic balance in healthy individuals and obese standard treated type 2 diabetes. Metabolism 65:1695-1705
Gilchuk, Pavlo; Hill, Timothy M; Guy, Clifford et al. (2016) A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Rep 16:1800-9
Jones, Hendrée E; Seashore, Carl; Johnson, Elisabeth et al. (2016) Measurement of neonatal abstinence syndrome: Evaluation of short forms. J Opioid Manag 12:19-23

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