An interaction between the renin-angiotensin-aldosterone system (RAAS) and fibrinolytic system has been postulated to be related w/an increased risk of cardiovascular events due to the activation of the RAAS. The purpose of the present study is to test the hypotheses that aldosterone increases PAI-1 syntheses in humans.
SPECIFIC AIMS : 1) To test the hypothesis that aldosterone increases PAI-1 by comparing the effects of placebo, the thiazide diuretic hydrochlorothiazide and the aldosterone receptor antagonist spironolactone on fibrionolytic balance in hypertensive subjects. 2) To determine whether specific aldosterone receptor antagonism, like ACE inhibition, improves endothelial function in patients w/hypertension.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000095-40
Application #
6409578
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1977-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203
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