AT1 receptor antagonist, candesartan, and the aldosterone antagonist, spironolactone, will interact to decrease PAI-1 synthesis under conditions of activation of the RAAS.
SPECIFIC AIM : To test the hypothesis that aldosterone and Ang II increase PAI-1 by comparing the effects of placebo, AT1 receptor blocker candesartan, and the aldosterone receptor antagonist spironolactone on fibrinolytic system in healthy subjects.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000095-40
Application #
6409643
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1977-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203
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