This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Medication and physican prescribing practices have a significant impact on the course of asthma. Several studies hav documented that the major factors contributing to asthma morbidity are underdiagnosis and inappropriate treatment. The objectives of this application are to study the relationship between asthma control and medication utilization. We hypothesize that certain patterns of medication utilization are a timely surrogate for increasing asthma symptoms and thus a better predictor to those at resk for hospitalization than patient reports of asthma symptoms or peak flow rates. The goal of these analyses will be to (1) develop a computerized pharmacy-based drug utilization review program to identify, in a timely manner, those patients at a high risk of an asthma exacerbation, as well as physicians w/ inadequate
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