Ddi and Zvd Therapy for AIDS or Arc Patients on Long-Term Zvd Treatment

Valentine, Fred T.

Abstract

This is a phase-II/III to compare the efficacy and toxicity of 2', 3' dideoxyinosine (ddi) and zidovudive (ZVD) in patients with AIDS or advanced ARC who have received AZT for 12 months or longer. Patients will be assigned to one of two treatment arms under a double-blind,m randomly allocated experimental design. ddI will be administered orally at a dose of 375 mg twice daily, and ZVD orally at a dose of 200 mg every 4 hours.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000096-32
• Application #: 3785748
• Support Year: 32
• Fiscal Year: 1993

Institution

• Name: New York University
• DUNS #: 004514360
• City: New York
• State: NY
• Country: United States
• Zip Code: 10012

Publications

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Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150

Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17

Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-129

Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43

Li, Yi; Tsui, Wai; Rusinek, Henry et al. (2015) Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. J Nucl Med 56:270-3

Ghani, Mahdi; Reitz, Christiane; Cheng, Rong et al. (2015) Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. JAMA Neurol 72:1313-23

Beecham, Gary W; Dickson, Dennis W; Scott, William K et al. (2015) PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology 84:972-80