This Phase I study attempts to establish the maximum tolerated dose and dose limiting toxicity of low dose continuous infusion topotecan in combination with 5-Fluorouracil for advanced malignancies and establish a recommended Phase II dose based on the MTD. Pharmacokinetic and pharmacodynamic studies of topotecan will be done. Anti-tumor activity will be assessed.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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