Genetic deficiency of lysosomal acid alpha glucosidase or acid maltase results in glycogen storage disease type II (GSDII) or acid maltase deficiency. Currently there is no treatment or cure for GSDII. The goal of the investigator is to evaluate enzyme replacement therapy to correct the genetic defect in the various forms of the disease. One of the problems is obtaining enough enzyme for longterm treatment of patients.
The aim of this protocol is to see if plants can produce sufficient quantities of a functional enzyme. The Core Laboratory was utilized for DNA Isolation, DNA sequencing (manual), oligonucleotide synthesis, and Recombinant DNA techniques.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000096-39
Application #
6412510
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1975-10-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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