This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Obesity has been considered to be a risk factor for gastroesophageal reflux disease (GERD). Several studies have shown that while there are obese patients with GERD, the incidence of obese patients with symptomatic GERD was no greater than in a population of normal-weight control patients. In addition, reduced lower esophageal sphincter pressure (LESP) was not more common in the obese than in the controls. Finally, there is controversy about whether weight loss improves symptoms in patients with GERD who are overweight.Patients with morbid obesity who undergo gastric restrictive weight loss procedures are successful in losing weight. Two restrictive procedures in use are the vertical band gastroplasty (VBG) and the adjustable laparoscopic band (Lap-Band). GERD and esophageal motility disturbances have been reported post-operatively in these patients.It is also known that obesity (BMI >35) is a risk factor for obstructive sleep apnea (OSA), more significantly in males. The factors involved in this association are still under investigation. Body fat distribution, hormonal differences and, recently, leptin levels have been suggested as possible etiologies of obesity. Leptin deficiency has been suggested as playing a role in other related respiratory disorders, such as obesity hypoventilation syndrome. There have also been several studies assessing the association of GERD and sleep disturbances. Recumbent posture has been considered a factor in GERD and 'reactive' esophageal clearance mechanisms are hindered by the recumbent posture and are inoperative during sleep, rapid eye movement sleep.In this proposal, the investigators aim to study the impact of weight loss after bariatric surgery on esophageal function and sleep. Primary goals are as follows: 1) test the hypothesis that obese patients will have a change from baseline in esophageal motility measured by manometry; 2) examine the change of 24-hour pH study from baseline; 3) examine the change of GERD symptoms score from baseline. Secondary goals are as follows: 1) examine if there are changes in gastrin, pepsinogen, leptin, and ghrelin six months and twelve months after bariatric surgery compared with patients' own baseline preoperatively; 2) examine the change of Helicobacter pylori status in obese patients with and without GERD symptoms; 3) examine nocturnal reflux and sleep disturbances in obese patients pre and post Lap-Band surgery.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000096-46
Application #
7605707
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
46
Fiscal Year
2007
Total Cost
$14,952
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-129
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
Homann, O R; Misura, K; Lamas, E et al. (2016) Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness. Mol Psychiatry 21:1690-1695
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Li, Yi; Tsui, Wai; Rusinek, Henry et al. (2015) Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. J Nucl Med 56:270-3
Ghani, Mahdi; Reitz, Christiane; Cheng, Rong et al. (2015) Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. JAMA Neurol 72:1313-23
Beecham, Gary W; Dickson, Dennis W; Scott, William K et al. (2015) PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology 84:972-80

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