Clinic patients are screened for severe hypertriglyceridemia. Post-heparin lipolyte activity is determined. The DNA sequence of candidate genes such as apoliprotein-III and lipoprotein lipase are examined to identify possible causative mutations. Allele specific oligonucleotides are constructed to search for these mutations in others with a similar phenotype or in the general population.

Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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