Abstract

Epidermolysis bullosa (EB) refers to a group of rare, inherited dermatoses characterized by blisters and erosions at the sites of minor trauma. Staphylococcal infections are a common complication in these patients. Preliminary studies suggest that more than half of patients with EB are chronic nasal carriers. In other patient populations, such as patients undergoing hemodialysis or those with surgical wounds or burns, nasal carriage of staphylococci is associated with recurrent skin or wound infection with these organisms.
The aim of this study is to determine the efficacy of intranasal mupirocin ointment in eradication of nasal carriage of staphylococci in patients with EB. If this preliminary trial is successful, the effects of diminished nasal carriage on recurrent skin and wound infections will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000102-33
Application #
5219613
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Pendyala, Swaroop; Walker, Jeanne M; Holt, Peter R (2012) A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142:1100-1101.e2

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