Abstract

The primary purpose of this study is to evaluate the safety of CP-195,543 in subjects with psoriasis vulgaris. CP-195,543 is a leukotriene b4 (LTB4)-inhibitor with demonstrated anti-inflammatory activity. Over one hundred subjects fulfilling eligibility criteria who have documented psoriasis will be randomized to receive six weeks of therapy with 50 or 25 mg CP-195,543 or placebo four times daily. A subset of the subjects on this study will also undergo a subcutaneous challenge with LTB4 on areas of skin not affected by psoriasis. At one week then biweekly intervals, all subjects will be evaluated for safety and toleration of therapy. The effect of CP-195,543 at these two doses on laboratory and clincal safety studies and on clinical manifestations and histopathology of psoriasis will be measured. Those subjects undergoing the LTB4 challenge will have cutaneous responses evaluated prior to and at the end of therapy. A secondary objective is to assess the anti-inflammatory activity of CP-195,543 to a direct cutaneous challenge with LTB4.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000102-35S1
Application #
6115903
Study Section
Project Start
1997-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
35
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

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Ansar, Muhammad; Raza, Syed Irfan; Lee, Kwanghyuk et al. (2015) A homozygous missense variant in type I keratin KRT25 causes autosomal recessive woolly hair. J Med Genet 52:676-80
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Ohmatsu, Hanako; Humme, Daniel; Gulati, Nicholas et al. (2014) IL32 is progressively expressed in mycosis fungoides independent of helper T-cell 2 and helper T-cell 9 polarization. Cancer Immunol Res 2:890-900
Alemán, José O; Eusebi, Leonardo H; Ricciardiello, Luigi et al. (2014) Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 146:357-373
Barbuto, Scott; Idoyaga, Juliana; Vila-Perelló, Miquel et al. (2013) Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nat Chem Biol 9:250-6
Guo, Xiuyang; Dhodapkar, Kavita M (2012) Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells. Hum Immunol 73:871-8
Dustin, Lynn B; Charles, Edgar D (2012) Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. Antivir Ther 17:1449-52
Pendyala, Swaroop; Walker, Jeanne M; Holt, Peter R (2012) A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142:1100-1101.e2

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