This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescents who suffer from Attention-Deficit/Hyperactivity Disorder (ADHD) appear to be at substantially higher risk of becoming cigarette smokers than non-ADHD adolescents. One reason for this may be that nicotine, the psychoactive ingredient in tobacco, may have beneficial effects on some of the symptoms of ADHD making the experience of smoking more reinforcing for individuals with ADHD. We have preliminary evidence that nicotine has acute positive effects on some of the core cognitive deficits in ADHD. We believe that nicotine may also have positive effects on motor functioning in ADHD, and that the positive effects on nicotine on both cognitive and motor symptoms may contribute substantially to the higher risk of chronic tobacco use/abuse in these adolescents and adults.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000109-42
Application #
7378583
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-05-09
Project End
2007-02-28
Budget Start
2006-05-09
Budget End
2007-02-28
Support Year
42
Fiscal Year
2006
Total Cost
$11,171
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
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Kien, C Lawrence; Bunn, Janice Y; Fukagawa, Naomi K et al. (2015) Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem 26:1599-606
Fox, James R; Gray, Weili; Koptiuch, Cathryn et al. (2014) Anisotropic tissue motion induced by acupuncture needling along intermuscular connective tissue planes. J Altern Complement Med 20:290-4

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