This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The both complementary and alternative medicine practice of therapeutic fasting is currently recommended as a treatment of besity and other metabolic diseases. Obesity is currently the most significant nutritional disorder in the United States and a reduction in the prevalence of obesity is targeted as a major objective in 'Healthy People 2010'. However, despite these goals, the prevalence of obesity is continuing to rise. New treatment options for obesity are desperately needed. The weight loss and metabolic benefits of traditional caloric restriction tend to be small and short lived. There are strong data to support a variety of benefits and durability of weight loss with therapeutic fasting. However, persistent fasting is not practical and has increased associated adverse events. Recently, animal data suggest that intermittent fasting (every other day) has similar metabolic benefits to prolonged fasting. There are also data to suggest that intermittent fasting will be safer than prolonged fasting and easier to tolerate than traditional caloric restriction. The studies described in this pilot study are designed to begin to test the overall hypothesis that therapeutic intermittent fasting (IF) will be a more effective treatment for obesity than moderate daily caloric restriction (CR). Specific hypotheses to be tested include: 1.Weight loss will be greater with IF compared to CR. 2.The metabolic profile including insulin sensitivity, lipid levels, and blood pressure will be more improved following IF compared to CR. 3.There will be greater participant adherence following IF compared to CR. Following baseline measurements, participants will be randomized to a standard caloric restriction diet or to intermittent fasting. Interim measures will be collected at one week, and follow up measures collected at eight weeks.
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