This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Amyotrophic lateral sclerosis (ALS) and its related motor neuron disorders are progressive, devastating neurological diseases causing muscle weakness, breathing failure, and death, usually within 3 to 5 years. In most patients, the cause is unknown. The ALS Research Group DNA Banking study will look at genetic factors which may contribute to the development of ALS. To do so, researchers need blood samples and some basic health-related medical and family history information from both ALS patients and controls. Controls are people who do not have ALS. This study will safely and anonymously collect blood samples and health-related medical and family history for future ALS research. A group of 10 ALS care and research centers and clinics in the United States and Canada, including the University of Vermont, are working together to collect and submit blood samples for DNA banking to the National Institute of Neurological Disorders and Strokes (NINDS) Human Genetics Repository at Coriell Medical Research Institute in Camden, NJ . The results of this study will provide a collection of genetic material from the blood samples of ALS patients, and create an important national tool for future studies on the causes of ALS.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000109-43
Application #
7605817
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-03-01
Project End
2008-02-29
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
43
Fiscal Year
2007
Total Cost
$6,106
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
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Miller, Mark S; Bedrin, Nicholas G; Ades, Philip A et al. (2015) Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area. Am J Physiol Cell Physiol 308:C473-84
Kien, C Lawrence; Bunn, Janice Y; Fukagawa, Naomi K et al. (2015) Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. J Nutr Biochem 26:1599-606
Wills, Anne-Marie; Hubbard, Jane; Macklin, Eric A et al. (2014) Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 383:2065-2072

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