Clinical observation suggests that cognitive function can remain impaired after hypoglycemia, despite normalization of plasma glucose. To determine that such a delay occurs, and whether it is influenced by the duration of hypoglycemia, we compared P300 latency (prolongation is a marker of hypoglycemic cognitive dysfunction), after different periods of hypoglycemia. 17 normal volunteers had 2 hypoglycemic clamp studies. Plasma glucose was lowered to 50mg/dl for 60 or 180 min. P300 latency was measured at baseline, during hypoglycemia and during glucose recovery. All subjects showed P300 prolongation during hypoglycemia. No change was seen during 3 euglycemic control studies. We plan to measure the delay in normalization of cognitive function after hypoglycemia in poorly controlled diabetics, we expect this will be more prolonged.

Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1996
Total Cost
Indirect Cost
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