Simultaneous abuse of cocaine and alcohol is widespread and increasingly detected in patients seeking emergency care. Physiological and behavioral effects of multiple doses of cocaine and alcohol in humans as compared to multiple doses of either drug alone were determined in this double-blind, randomized, within-subjects study using a paradigm more closely approximating practices of drug abusers. Combined administration of cocaine and alcohol produced greater euphoria and increased preception of well-being relative to cocaine. Heart rate was significantly increased following cocaine-alcohol administration. Cocaethylene, detected only following cocaine-alcohol administration, had a longer half-life with increasing plasma concentrations relative to cocaine at later time points. Enhanced psychological effects experienced during cocaine-alcohol abuse may encourage ingestion of larger amounts of these substances over time placing the user at heightened risk for toxic effects, particularly cardiovascular toxicity, than with either drug alone. Future plans include continuation of this study with recruitment of equal number of men and women to obtain a sample size (14 men and 14 women) which will permit an analysis of cocaine and alcohol effects by gender.

Project Start
1997-04-01
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
34
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
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Gidding, Samuel S; Bacha, Fida; Bjornstad, Petter et al. (2018) Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr 192:86-92.e5
Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Kelsey, Megan M; Geffner, Mitchell E; Guandalini, Cynthia et al. (2016) Presentation and effectiveness of early treatment of type 2 diabetes in youth: lessons from the TODAY study. Pediatr Diabetes 17:212-21

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