The purpose of ths study is to measure the hypothalamic-pituitary- adrenal axis (HPA) axis function and the hippocampus in women with Posttraumatic Stress Disorder (PTSD) related to childhood sexual abuse. The study will entail measurement of hippocampal volume with MRI, assessment of memory function with neuropsychological testing, 24 hour measurement of plasma cortisol, ACTH and Beta-endorphin, a CRF and ACTH challenge test and administraion of dexamethasone with measurement of memory function.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
35
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
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Kelsey, Megan M; Geffner, Mitchell E; Guandalini, Cynthia et al. (2016) Presentation and effectiveness of early treatment of type 2 diabetes in youth: lessons from the TODAY study. Pediatr Diabetes 17:212-21

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