The primary aim of this study was to explore the feasibility of conducting a larger study investigating the efficacy of acupuncture on symptom distress and quality of life in individuals with HIV-infection. Results: Recruitment procedures revealed that many interested potential participants who were well enough to work, but symptomatic with HIV infection were unable to enroll in the project due to the time frame commitments of treatments twice per week for a three week period. The instruments were easily understood by the participants in this setting, and were sensitive to changes in participants' status subsequent to treatment differences. There were no negative incidents in response to the acupuncture. Pooled data for the participants who completed the midpoint and end of study data collection showed trends towards significance. Changes in the FAHI (Functional Assessment of HIV Infection Scale Version 3) physical well being scores and the BSI (Brief Symptom Inventory) somatic complaint scores were consistent with symptom improvement, which was also seen in the scores for the HIV-SL (HIV-Symptom list). Pooled data on change of mean number of symptoms indicated a decrease from a baseline of 14, to midpoint measure of 8(p<.05), and an exit mean of 6.5 symptoms (p<.05). Conclusions: The instruments and intervention were appropriate for use with our population, although the treatment schedule was unrealistically demanding for much of our client population. Preliminary data from small number of participants showed trends toward improvement in symptoms and quality of life. A Phase Two study will be conducted to refine the interventions dose (frequency of treatments), in preparation for conducting a large randomized clinical trial.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
36
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kelsey, Megan M; Braffett, Barbara H; Geffner, Mitchell E et al. (2018) Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab 103:2309-2318
Kleinberger, Jeffrey W; Copeland, Kenneth C; Gandica, Rachelle G et al. (2018) Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med 20:583-590
Berkowitz, Robert I; Marcus, Marsha D; Anderson, Barbara J et al. (2018) Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial. Pediatr Diabetes 19:191-198
Kriska, Andrea; El Ghormli, Laure; Copeland, Kenneth C et al. (2018) Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes 19:36-44
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Venditti, E M; Tan, K; Chang, N et al. (2018) Barriers and strategies for oral medication adherence among children and adolescents with Type 2 diabetes. Diabetes Res Clin Pract 139:24-31
Gidding, Samuel S; Bacha, Fida; Bjornstad, Petter et al. (2018) Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr 192:86-92.e5
Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Chernausek, Steven D; Arslanian, Silva; Caprio, Sonia et al. (2016) Relationship Between Parental Diabetes and Presentation of Metabolic and Glycemic Function in Youth With Type 2 Diabetes: Baseline Findings From the TODAY Trial. Diabetes Care 39:110-7

Showing the most recent 10 out of 343 publications