This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.ABSTRACTHYPOTHESIS AND SPECIFIC AIMSOur overall objective is to provide a rational basis for establishing dietary mineral recommendations in toddlers and small children (ages 12 through 48 months) by measuring the absorptionand utilization of minerals at various intake levels relative to current usual intakes.Specific objective #1: To compare the absorption of calcium, zinc, iron, copper and magnesium in children receiving diets containing the median (50th percentile) of US intakes for these minerals to diets containing the 25th percentile and 75th percentile of US intakes of these minerals.Hypothesis #1: There will be significantly greater total absorption at the 75th percentile of US intakes than at either 50th percentile or 25th percentile for each mineral indicating that threshold intakes have not been reached at the 50th percentile of US intakes.Specific objective #2: To determine the relationship between mineral intake and enogenous fecal excretion of calcium and zinc over the range of intakes from the 25th percentile to the 75th percentile of US population intakes.Hypothesis #2: Total calcium absorption will be significantly positively correlated with endogenous fecal calcium excretion. Similarly, total zinc absorption will be significantly positively correlated with endogenous fecal zinc excretion. This correlation will be closer and have a greater slope for zinc than for calcium reflecting the greater importance of endogenous fecalexcretion in regulating zinc relative to calcium balance.
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