This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Survivors of childhood Acute Lymphocytic Leukemia (ALL) are at increased risk for obesity, insulin resistance, and metabolic syndrome. While it is well established that hyperglycemia during treatment for ALL predicts adverse outcomes such as infections and death, the association with co-morbidities seen in survivors remains unknown. We hypothesize that survivors of childhood ALL with a history of hyperglycemia during induction are at increased risk to develop insulin resistance and metabolic syndrome when compared to euglycemic counterparts. Methods: We plan to conduct a prospective study of 40 survivors of childhood ALL who were diagnosed 1999-2006 and are currently cared for in the Texas Childrens Cancer Center Long-Term Survivor Clinic. Subjects will be divided equally into 2 groups based on presence or absence of hyperglycemia during induction therapy for ALL. Each subject will undergo an oral glucose tolerance test and a DEXA scan for body composition along with measurements of insulin resistance, lipids, and blood pressure. A 2 sample t-test will be used to compare mean insulin resistance between the 2 groups. A chi 2 analysis will be performed for outcomes such as metabolic syndrome, hypertension, dyslipidemia, and obesity. Results/Conclusions: We expect to detect a significant difference in insulin resistance, measured as HOMA, of 2.4 between our two groups. We predict that survivors of ALL with a history of hyperglycemia compared to those who remained euglycemic during induction will be more likely to exhibit insulin resistance. Additionally, we expect to find higher rates of co-morbidities such as impaired glucose tolerance, obesity, hypertension, dyslipidemia, and metabolic syndrome in the hyperglycemia group. If our hypotheses are proven, future studies will be needed to examine the role of hyperglycemia therapy during induction as a means of decreasing co-morbidities in ALL survivors.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000188-47
Application #
8356755
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2010-12-01
Project End
2011-11-30
Budget Start
2010-12-01
Budget End
2011-11-30
Support Year
47
Fiscal Year
2011
Total Cost
$3,562
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Hunsaker, Sanita L; Garland, Beth H; Rofey, Dana et al. (2018) A Multisite 2-Year Follow Up of Psychopathology Prevalence, Predictors, and Correlates Among Adolescents Who Did or Did Not Undergo Weight Loss Surgery. J Adolesc Health 63:142-150
Lanzieri, Tatiana M; Chung, Winnie; Leung, Jessica et al. (2018) Hearing Trajectory in Children with Congenital Cytomegalovirus Infection. Otolaryngol Head Neck Surg 158:736-744
Bollard, Catherine M; Tripic, Tamara; Cruz, Conrad Russell et al. (2018) Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma. J Clin Oncol 36:1128-1139
Michalsky, Marc P; Inge, Thomas H; Jenkins, Todd M et al. (2018) Cardiovascular Risk Factors After Adolescent Bariatric Surgery. Pediatrics 141:
Lau, Chantal (2018) Breastfeeding Challenges and the Preterm Mother-Infant Dyad: A Conceptual Model. Breastfeed Med 13:8-17
Gururangan, Sridharan; Reap, Elizabeth; Schmittling, Robert et al. (2017) Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11). Cancer Immunol Immunother 66:1589-1595
Lanzieri, T M; Leung, J; Caviness, A C et al. (2017) Long-term outcomes of children with symptomatic congenital cytomegalovirus disease. J Perinatol 37:875-880
El-Hattab, Ayman W; Zarante, Ana Maria; Almannai, Mohammed et al. (2017) Therapies for mitochondrial diseases and current clinical trials. Mol Genet Metab 122:1-9
Jin, Haoxing Douglas; Demmler-Harrison, Gail J; Coats, David K et al. (2017) Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 36:877-882
Oh, Sam S; Du, Randal; Zeiger, Andrew M et al. (2017) Breastfeeding associated with higher lung function in African American youths with asthma. J Asthma 54:856-865

Showing the most recent 10 out of 459 publications