Abstract

This study intends to clarify the unexplained and inappropriate renal loss of phosphate in patients with tumor-induced osteomalacia (oncogenic hypophosphatemic osteomalacia). This syndrome is almost certainly caused by a humor factor. Studies will be constructed to assess renal tubular function in these patients and to investigate thei serum for causing alterations in phosphate transport in 2 different cultured cell lines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000229-25
Application #
3885854
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Upstate Medical University
Department
Type
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210

  Publications

Streeten, D H (1995) Idiopathic edema. Pathogenesis, clinical features, and treatment. Endocrinol Metab Clin North Am 24:531-47
Breslau, N A; Weinstock, R S (1988) Regulation of 1,25 (OH)2D synthesis in hypoparathyroidism and pseudohypoparathyroidism. Am J Physiol 255:E730-6
Haas, D C; Anderson Jr, G H; Streeten, D H (1985) Role of angiotensin in lethal cerebral hypoperfusion during treatment of acute hypertension. Arch Intern Med 145:1922-4