The primary goal of this project is to design and implement a multi-institutional, open-label phase I/II study of hydroxurea (HU) therapy in children with sickle cell disease. To achieve this main goal, the project has four specific aims: 1) To determine if HU will elevate the concentration of fetal hemoglobin, hemtocrit and red cell mean corpsucular volume in children with sickle cell anemia between the ages of 5 and 18 years. 2) To determine if the therapeutic dose of HU in pediatric patients is similar to that in adults. 3) To determine if the hematologic and renal toxicities in children are similar to those in adults. 4) To determine if there are adverse effects on growth in children taking HU.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000240-35S1
Application #
6219791
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
35
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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