Participants eligible for a research study of the ITREL II Deep Brain Stimulation (DBS) system will have Parkinson's Disease that is poorly controlled by oral medications. The goal of this feasibility study is to determine the safety and efficacy (effectiveness) of the DBS system in controlling symptoms (difficulty in moving, walking or standing up from a chair (akinesia), uncontrolled movements of large amplitude (dyskinesias), tremor, rigidity, etc.). The device will not treat the underlying condition. The system consists of an implanted portion and an external portion. The implanted portion consists of two electrodes which are placed in the brain and connected to two temporary pulse generators. The temporary pulse generator and its connecting wire will be removed later (during internalization) and will be replaced with permanent extension wires that run under the skin to two implanted pulse generators (similar to an implantable heart pacemaker). The implanted pulse generators (IPGs) are positioned under the skin, usually below the clavicle (collarbone). The IPGs produce the electrical stimulation that is sent through the leads to the electrodes. The external portion of the system consists of a magnet that turns the IPGs on and off and allows the choice between two physician-set stimulation levels. Although the surgical operational techniques used to implant the DBS system and the DBS system itself are not experimental, bilateral deep brain stimulation for treatment of symptoms is investigational. Participation in this study will last two years.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
34
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Brenowitz, Willa D; Keene, C Dirk; Hawes, Stephen E et al. (2017) Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging 53:83-92
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662
Bergstrom, Colin P; Ruffell, Brian; Ho, Christine M T et al. (2017) Docetaxel and mitoxantrone before radical prostatectomy in men with high-risk prostate cancer: 10-year follow-up and immune correlates. Anticancer Drugs 28:120-126
Narayanan, Kumar; Uy-Evanado, Audrey; Teodorescu, Carmen et al. (2016) Mitral valve prolapse and sudden cardiac arrest in the community. Heart Rhythm 13:498-503
Abner, Erin L; Nelson, Peter T; Kryscio, Richard J et al. (2016) Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimers Dement 12:882-9
Sylwester, Andrew; Nambiar, Kate Z; Caserta, Stefano et al. (2016) A new perspective of the structural complexity of HCMV-specific T-cell responses. Mech Ageing Dev 158:14-22
Elliot, Diane; Garg, Bharti; Kuehl, Kerry et al. (2015) Why Are Women Law Enforcement Officers More Burned-Out and What Might Help Them? Occup Med Health Aff 3:
Samuels, Mary H (2014) Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes 21:377-83
Redig, Jennifer K; Fouad, Gameil T; Babcock, Darcie et al. (2014) Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genet 1:1-19
Lee, David S H; Markwardt, Sheila; Goeres, Leah et al. (2014) Statins and physical activity in older men: the osteoporotic fractures in men study. JAMA Intern Med 174:1263-70

Showing the most recent 10 out of 336 publications