Abstract

This research will study patients who are experiencing an acute rejection of a transplanted kidney. Participants will receive an investigational new medication, HuM291, that will be given intravenously (IV). The purpose of this study is to examine the effect and safety of different amounts of HuM291 given in 3 doses to kidney transplant recipients experiencing a mild to moderate rejection. The length of participation in this study will be 104 days. This medication is a humanized monoclonal antibody that is made in a laboratory. Antibodies are proteins made by the body that help us fight infection or invasion by foreign substances. Antibodies work by clamping onto germs or invading substances. Normally our bodies do not make antibodies that clamp on, or bind to our own tissues, but mice can produce antibodies that bind to human tissues. Mouse antibodies can be changed in a laboratory so that they are almost exactly like human antibodies. This type of antibody is called a """"""""humanized monoclonal antibody."""""""" HuM291 is a humanized monoclonal antibody that is made in a laboratory. HuM291 binds to parts of T cells and causes them to decrease their function. This has the effect of lowering immunity but it may also help reverse rejection of the kidney.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000334-34
Application #
6411440
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1976-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
34
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

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Abner, Erin L; Nelson, Peter T; Kryscio, Richard J et al. (2016) Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimers Dement 12:882-9
Sylwester, Andrew; Nambiar, Kate Z; Caserta, Stefano et al. (2016) A new perspective of the structural complexity of HCMV-specific T-cell responses. Mech Ageing Dev 158:14-22
Elliot, Diane; Garg, Bharti; Kuehl, Kerry et al. (2015) Why Are Women Law Enforcement Officers More Burned-Out and What Might Help Them? Occup Med Health Aff 3:
Samuels, Mary H (2014) Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes 21:377-83
Redig, Jennifer K; Fouad, Gameil T; Babcock, Darcie et al. (2014) Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genet 1:1-19
Lee, David S H; Markwardt, Sheila; Goeres, Leah et al. (2014) Statins and physical activity in older men: the osteoporotic fractures in men study. JAMA Intern Med 174:1263-70

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