EXCEED THE SPACE PROVIDED.The GCRC at the Oregon Health and Science University (OHSU) has been continuously supported by the NIH for38 years, and has an outstanding record of achievement. With an overarching objective of increasing both the scopeand excellence of clinical research, the GCRC has changed in several key areas since the last renewal. It has been animportant contributor to a phase of rapid research growth at OHSU by providing new resources and participating inthe planning/administration of research policy. Several new GCRC initiatives have been funded with competitivesupplements, including a genetics/molecular biology component of the Core Lab, a Body Energy and CompositionCore, and an expanded Informatics Core. Each of these has been very successful; as a result, the scope and diversityof supported research has expanded. In addition, the GCRC has become an integral part of a new institutional clinicalresearch support system (the Clinical Research Program). This has deepened the already excellent support the GCRCenjoys from the Institutional Review Board, the hospital and research administration, and the campus-wide computernetwork. Moreover, since the last renewal the GCRC has become extensively integrated into the decision-making andplanning processes of the institution. This has provided advantages for GCRC investigators and staff, and hasextended the institution's support of clinical research. Increasingly, the GCRC is an important component of trainingin clinical research methodology.This application requests additional support for grant years 39-44. In light of the rapid growth in the number ofsupported protocols, census, and lab/bionutrition services since the last renewal, modest increases in support ofnursing, lab, bionutrition, and compliance are necessary to meet existing investigator needs even without consideringthe high likelihood of continued growth. OHSU has recently invested extensively in an Advanced Imaging ResearchCenter. As an essential partner, the GCRC is intended to provide investigator support for clinical research that utilizesimaging techniques. Support is requested for a GCRC Imaging Core. Finally, the growth in protocols involvingresearch pharmaceuticals necessitates a research pharmacist who will serve GCRC investigators and participants inconjunction with a new OHSU Research Pharmacy.At OHSU the GCRC is in a phase of growth and diversification. It has enormous support from the institution and itseeks continued funding to fulfill the expectation that it will provide a vital new focus for clinical research both inOregon and nationally.
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