Abstract

The objective of this study is to test the hypotheses that: 1) patients with IDDM have circadian changes in insulin sensitivity; 2) these changes are caused by circadian changes in hepatic glucose production and 3) that the circadian changes in hepatic glucose production can be altered with Metformin. The findings are likely to be of considerable clinical importance. Metformin is known to lower blood glucose by suppressing HGP. We hypothesize that it will be able to inhibit circadian nocturnal HGP and improve/facilitate glycemic control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000349-32
Application #
6117003
Study Section
Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
32
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Blanco, Carlos; Heimberg, Richard G; Schneier, Franklin R et al. (2010) A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry 67:286-95
Salerno, Dominic; Hasham, Muneer G; Marshall, Renee et al. (2007) Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene 405:65-78
Heimberg, Richard G; Holaway, Robert M (2007) Examination of the known-groups validity of the Liebowitz Social Anxiety Scale. Depress Anxiety 24:447-54
Schultz, Luke T; Heimberg, Richard G; Rodebaugh, Thomas L et al. (2006) The appraisal of social concerns scale: psychometric validation with a clinical sample of patients with social anxiety disorder. Behav Ther 37:392-405
Marshall, Renee M; Grana, Xavier (2006) Mechanisms controlling CDK9 activity. Front Biosci 11:2598-613
Hughes, Alicia A; Heimberg, Richard G; Coles, Meredith E et al. (2006) Relations of the factors of the tripartite model of anxiety and depression to types of social anxiety. Behav Res Ther 44:1629-41
Rodebaugh, Thomas L; Woods, Carol M; Heimberg, Richard G et al. (2006) The factor structure and screening utility of the Social Interaction Anxiety Scale. Psychol Assess 18:231-7
Gonlachanvit, S; Maurer, A H; Fisher, R S et al. (2006) Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 18:894-904
Gaddipati, Kishore V; Simonian, Hrair P; Kresge, Karen M et al. (2006) Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci 51:1339-46
Simonian, Hrair P; Vo, Lien; Doma, Siva et al. (2005) Regional postprandial differences in pH within the stomach and gastroesophageal junction. Dig Dis Sci 50:2276-85

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