Abstract

This is a pilot study involving 2 patients in which a drug - Pyrazinoyl will be studied to assess its effect on lipid and carbohydrate metabolism. This agent has been shown in humans (and rats) to decrease blood glucose in patients with diabetes, and the mechanism is thought to be via its ability to lower plasma FFA and triglyceride concentration. The lipid lowering effect is believed to result from its inhibition of lipolysis secondary to activation of adipose tissue phosphodiesterase activity and a decrease in cAMP.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000349-34
Application #
6420645
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
34
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Blanco, Carlos; Heimberg, Richard G; Schneier, Franklin R et al. (2010) A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry 67:286-95
Salerno, Dominic; Hasham, Muneer G; Marshall, Renee et al. (2007) Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene 405:65-78
Heimberg, Richard G; Holaway, Robert M (2007) Examination of the known-groups validity of the Liebowitz Social Anxiety Scale. Depress Anxiety 24:447-54
Schultz, Luke T; Heimberg, Richard G; Rodebaugh, Thomas L et al. (2006) The appraisal of social concerns scale: psychometric validation with a clinical sample of patients with social anxiety disorder. Behav Ther 37:392-405
Marshall, Renee M; Grana, Xavier (2006) Mechanisms controlling CDK9 activity. Front Biosci 11:2598-613
Hughes, Alicia A; Heimberg, Richard G; Coles, Meredith E et al. (2006) Relations of the factors of the tripartite model of anxiety and depression to types of social anxiety. Behav Res Ther 44:1629-41
Rodebaugh, Thomas L; Woods, Carol M; Heimberg, Richard G et al. (2006) The factor structure and screening utility of the Social Interaction Anxiety Scale. Psychol Assess 18:231-7
Gonlachanvit, S; Maurer, A H; Fisher, R S et al. (2006) Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 18:894-904
Gaddipati, Kishore V; Simonian, Hrair P; Kresge, Karen M et al. (2006) Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci 51:1339-46
Simonian, H P; Kresge, K M; Boden, G H et al. (2005) Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:348-54

Showing the most recent 10 out of 102 publications