Abstract

The aims of this protocol are to determine whether the normal lining of the esophagus in patients with Barrett's epithelium (a premalignant condition) can be restored by ablating the abnormal mucosa with endoscopic laser therapy and to determine whether the restoration of normal esophageal mucosa can be accelerated and prolonged by suppressing acid within the esophagus with medications vs Nissen fundoplication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000349-35
Application #
6567402
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
35
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Blanco, Carlos; Heimberg, Richard G; Schneier, Franklin R et al. (2010) A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry 67:286-95
Salerno, Dominic; Hasham, Muneer G; Marshall, Renee et al. (2007) Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene 405:65-78
Heimberg, Richard G; Holaway, Robert M (2007) Examination of the known-groups validity of the Liebowitz Social Anxiety Scale. Depress Anxiety 24:447-54
Schultz, Luke T; Heimberg, Richard G; Rodebaugh, Thomas L et al. (2006) The appraisal of social concerns scale: psychometric validation with a clinical sample of patients with social anxiety disorder. Behav Ther 37:392-405
Marshall, Renee M; Grana, Xavier (2006) Mechanisms controlling CDK9 activity. Front Biosci 11:2598-613
Hughes, Alicia A; Heimberg, Richard G; Coles, Meredith E et al. (2006) Relations of the factors of the tripartite model of anxiety and depression to types of social anxiety. Behav Res Ther 44:1629-41
Rodebaugh, Thomas L; Woods, Carol M; Heimberg, Richard G et al. (2006) The factor structure and screening utility of the Social Interaction Anxiety Scale. Psychol Assess 18:231-7
Gonlachanvit, S; Maurer, A H; Fisher, R S et al. (2006) Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 18:894-904
Gaddipati, Kishore V; Simonian, Hrair P; Kresge, Karen M et al. (2006) Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci 51:1339-46
Simonian, H P; Kresge, K M; Boden, G H et al. (2005) Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:348-54

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