The purpose of this study is to identify the undesirable side effects of HMG-COA reductase inhibitors on skeletal muscle metabolism and fatigue in hypercholesterolemic subjects. Also, this study will provide credence to hypothesis that highly lipid soluble drugs such as lovastatin and simvastatin may exacerbate the myalgic effects, caused by strenuous eccentric exercise; whereas highly hydrophilic drugs such as pravastatin may be relatively safer.

Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
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