Abstract

Informed consent are being sought from patients with epilepsy that metabolize AEDs at a slow rate (Group 1), at an average rate (Group( 2), and family members of the slow metabolizers (Group 3). Patients (Group 1), controls (Group 2), and family members (Group 3) will be brought to steady state with the AED that they normally take (Groups 1 and 2) or with a low dose of the AED that their family member from Group 1 is taking (Group 3). Participants will be asked to report to the CRC at the University of MN where they will be admitted for approximately 24 hours. The same dosage regimen (q12) will be continued throughout the patients' stay at the CRC. A small indwelling catheter will be inserted into a vein in the patient's forearm so that multiple blood samples can be conveniently taken. Patients will be asked ? collect their urine in o a container over a 24 hour period beginning just prior to the taking of the blood sample. Blood and urine specimens will be analyzed for blood chemistries (to assess liver function, kidney function, and the amount of protein binding) for creatinine clearance (to assess kidney function) and for the parent drug and metabolite concentrations (to assess the contribution of specific metabolic pathways to AED metabolism).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000400-28
Application #
5220367
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group; Krischer, Jeffrey P; Schatz, Desmond A et al. (2017) Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial. JAMA 318:1891-1902
Kotlyar, Michael; Thuras, Paul; Hatsukami, Dorothy K et al. (2017) Sex differences in physiological response to the combination of stress and smoking. Int J Psychophysiol 118:27-31
Cole, Abigail J; Kuchnia, Adam J; Beckman, Lauren M et al. (2017) Long-Term Body Composition Changes in Women Following Roux-en-Y Gastric Bypass Surgery. JPEN J Parenter Enteral Nutr 41:583-591

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