Protocol 533 addresses the mechanism involved in generating hypertension by mineralocorticoids. The most commonly accepted mechanism is that mineralocorticoids cause hypertension through salt retention and subsequent volume expansion. This study addresses another possibility, namely, direct vascular effects of aldosterone that are independent of volume retention. This is achieved by keeping dialysis patients at the same weight while receiving fludrocortisone.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
30
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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