This study is designed to describe the effects of Humotrope (GH) on bone mineral content and density (assessed by Dual Energy X-ray Absorptiometry (DEXA)), lean body mass, insulin-like-growth factors, bone markers, lipids, and Quality of Life in childhood-onset growth hormone-deficient (GHD) patients treated for two years after attainment of final height. A randomized, open-label, three-arm comparative, multi-national trial of 24-months duration, this investigation will be performed in childhood-onset GHD patients who had previously attained a final adult height while on growth hormone (GH) replacement therapy. Patients will be randomized to recieve one of two GH therapy doses, or no treatment (control group). Approximately 150 patients will participate at sites in the U.S. Up to five patients will participate at the University of Minnesota.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
33
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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