This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.B) This study is assessing the effect of 1 month of paraoxtine treatment on cardiovascular response and subjective discomfort during 2 mental stress tasks in smokers immediately after smoking a cigarette. Each subject receives one month of either paroxetine or placebo after which they return to the GCRC for a visit during which cardiovascular response is measured while performing two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. For the following month, subjects receive the alternate treatment after which response to the stress tasks is measured again.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000400-39
Application #
7606065
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-12-01
Project End
2007-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
39
Fiscal Year
2007
Total Cost
$49,376
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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