This multicenter randomized trial is designed to evaluate the ability of low dose insulin therapy, in association with periodic continuous insulin infusions ('beta cell rest') to delay and/or prevent the development of insulin dependent diabetes in first degree relatives of individuals with IDDM. Nondiabetic, islet cell antibody positive individuals who also have alterations in first phase insulin secretion are qualified for randomization. During the past year, approximately 100 IDDM families who had participated in previous studies of the genetics of diabetes were contacted and informed about the DPT-1 trial. Antibody screening of some interested family members was performed but no ICA+ individuals were identified. Recruitment will continue in the coming year.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
31
Fiscal Year
2000
Total Cost
$982
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
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