Congestive heart failure is a complex clinical syndrome often manifested by shortness of breath and fatigue. Because overt heart failure is characterized by activation of the renin-angiotensin system, angiotensin converting enzyme inhibitors are being used in congestive failure. Despite clinical trials showing efficacy of ACE inhibitors, mortality in congestive failure patients is still very high. The current study is designed to assess the utility of Valsartan, an orally active agent that competes with the receptors for angiotensin II, to see if it produces greater inhibition of the renin-angiotensin system and thus improves mortality and morbidity. Patient enrollment will continue in the coming year and previously enrolled patients will be followed for 24-36 months.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
31
Fiscal Year
2000
Total Cost
$982
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
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