This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to define the epidemiology of nosocomial funguria and natural history of patients that develop funguria while hospitalized.
The specific aims of this study are: 1) Identification of subsets of patients with funguria at risk for disseminated candidiasis and death. We will prospectively investigate this association, control for important confounders, and identify subgroups in which funguria is a significant predictor of invasive fungal infection. 2) Delineation of the long-term natural history of funguria. To clearly understand the potential impacts of funguria, long-term outcomes of persons with fungi isolated from the urine need to be described. We will study outcomes up to one year after initial isolation of fungi from the urine (NOTE: this subjproject will not be done at CSHS). 3) Determination of strain relatedness between fungi isolated from blood and urine. We plan to definitively answer the question of whether the two events are related in persons with contaminant funguria and fungemia by employing molecular-typing techniques to determine strain relatedness. 4) Understand host response to funguria by perfoming anitbiody tests on blood and urine specimens from patients with and without fungi in their urine or blood. Additional aspects of host response against fungi may be performed using genetic testing, if sufficient technology has been developed 5) Estimation of the national incidence of funguria and impact on resoucrce utilization. Because funguria is becoming so common, quantification of this problem will guide future studies in this area and will help with calculations of impacts of future interventions, such as efforts to reduce antifungal utilization in patients at low risk for complications from funguria.
Showing the most recent 10 out of 1232 publications
