This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is composed of two studies. Study 1 consists of 9 to 13 maintenance hemodialysis (MHD) patients who are clinically stable and will undergo nitrogen balance studies while they ingest, for 17 days each, diet protein intakes providing 0.60, 0.80, 1.00, 1.15 and 1.30 g protein/kg/day. 13 C-leucine turnover studies 13C-urea kinetic studies and measurements of plasma amino acides, dialysate amino acids, peptides and proteins, muscle biopsies for measurement of protein and gene expression for IGF-I, IGF-II, IGF-receptor, myostatin, and IGF-binding proteins and body composition (anthropometry and dual x-ray pohton absorptiometry (DXA)) will be measured. In Study 2, 70-80 MHD outpatients will be randomly assigned to a DPI of 1.00 or 1.30 g/kg/day for five months each. Total body protein will be assessed by measurements of total body nitrogen and total body potassium. Other components of body composition will be assessed using anthropometry, DXA, BIA and near infrared interactance.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000425-37
Application #
7376067
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
37
Fiscal Year
2006
Total Cost
$699,358
Indirect Cost
Name
La Biomed Research Institute/ Harbor UCLA Medical Center
Department
Type
DUNS #
069926962
City
Torrance
State
CA
Country
United States
Zip Code
90502
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