This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The AASK (African American Study of Patients with Hypertension-Related Kidney Disease) Cohort Study will be an extension of the AASK Study. This latter study examined the effects of two different levels of blood pressure control and three different types of blood pressure medicines on the progression of kidney failure and other clinical outcomes in African Americans with hypertension-caused kidney disease. This study has now ended, and it has been decided to offer the patients in the AASK Study the opportunity to remain in a study which will do no more than continue to monitor the patients. The patients will receive treatment for their hypertension and kidney disease according to the standard medical therapy and to judgement of their individual physician. Currently, Dr. Kopple is the only physician seeing the AASK patients who have chronic kidney disease and who are not treated with either dialysis or transplantation. The research effort in this study will be limited entirely to monitoring the patients. The key elements of the monitoring will include two main visits to the research clinic each year and two to four additional visits to manage the patients blood pressure. At the two main visits, patients will fill out questionnaires about their health and have blood drawn for various blood tests. Once, fingernail clippings will be obtained and an echocardiogram and ambulatory blood pressure monitoring will each be conducted in the first, third and fifth years. If patients agree, blood will also be drawn on one occasion for genetic testing; a written informed consent using a separate, additional consent form will be required before the genetic testing is done.
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