This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The AASK (African American Study of Patients with Hypertension-Related Kidney Disease) Cohort Study will be an extension of the AASK Study. This latter study examined the effects of two different levels of blood pressure control and three different types of blood pressure medicines on the progression of kidney failure and other clinical outcomes in African Americans with hypertension-caused kidney disease. This study has now ended, and it has been decided to offer the patients in the AASK Study the opportunity to remain in a study which will do no more than continue to monitor the patients. The patients will receive treatment for their hypertension and kidney disease according to the standard medical therapy and to judgement of their individual physician. Currently, Dr. Kopple is the only physician seeing the AASK patients who have chronic kidney disease and who are not treated with either dialysis or transplantation. The research effort in this study will be limited entirely to monitoring the patients. The key elements of the monitoring will include two main visits to the research clinic each year and two to four additional visits to manage the patients blood pressure. At the two main visits, patients will fill out questionnaires about their health and have blood drawn for various blood tests. Once, fingernail clippings will be obtained and an echocardiogram and ambulatory blood pressure monitoring will each be conducted in the first, third and fifth years. If patients agree, blood will also be drawn on one occasion for genetic testing; a written informed consent using a separate, additional consent form will be required before the genetic testing is done.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000425-38
Application #
7606144
Study Section
Special Emphasis Panel (ZRR1-CR-5 (01))
Project Start
2007-02-01
Project End
2007-11-30
Budget Start
2007-02-01
Budget End
2007-11-30
Support Year
38
Fiscal Year
2007
Total Cost
$1,800
Indirect Cost
Name
La Biomed Research Institute/ Harbor UCLA Medical Center
Department
Type
DUNS #
069926962
City
Torrance
State
CA
Country
United States
Zip Code
90502
Mehta, Puja K; Hermel, Melody; Nelson, Michael D et al. (2018) Mental stress peripheral vascular reactivity is elevated in women with coronary vascular dysfunction: Results from the NHLBI-sponsored Cardiac Autonomic Nervous System (CANS) study. Int J Cardiol 251:8-13
Kim, Se-Min; Cui, Jinrui; Rhyu, Jane et al. (2018) Association between site-specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women. Clin Endocrinol (Oxf) 88:848-855
Sharma, Shilpa; Mehta, Puja K; Arsanjani, Reza et al. (2018) False-positive stress testing: Does endothelial vascular dysfunction contribute to ST-segment depression in women? A pilot study. Clin Cardiol 41:1044-1048
Shufelt, Chrisandra; Manson, Joann (2018) Managing Menopause by Combining Evidence With Clinical Judgment. Clin Obstet Gynecol 61:470-479
Cherukuri, Lavanya; Smith, Michael S; Tayek, John A (2018) The durability of oral diabetic medications: Time to A1c baseline and a review of common oral medications used by the primary care provider. Endocrinol Diabetes Metab J 2:
Nicholls, Stephen J; Tuzcu, E Murat; Wolski, Kathy et al. (2018) Extent of coronary atherosclerosis and arterial remodelling in women: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. Cardiovasc Diagn Ther 8:405-413
Wei, Janet; Bakir, May; Darounian, Navid et al. (2018) Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease: From the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study. Circulation 137:874-876
Elboudwarej, Omeed; Wei, Janet; Darouian, Navid et al. (2018) Maladaptive left ventricular remodeling in women: An analysis from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Int J Cardiol 268:230-235
Shufelt, Chrisandra; Bairey Merz, C Noel; Pettinger, Mary B et al. (2018) Estrogen-alone therapy and invasive breast cancer incidence by dose, formulation, and route of delivery: findings from the WHI observational study. Menopause 25:985-991
Kenkre, Tanya S; Malhotra, Pankaj; Johnson, B Delia et al. (2017) Ten-Year Mortality in the WISE Study (Women's Ischemia Syndrome Evaluation). Circ Cardiovasc Qual Outcomes 10:

Showing the most recent 10 out of 1232 publications