This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: The prevalence of obstructive sleep disturbance (OSD) is significantly higher in children presenting with failure to thrive (FTT) than in children with normal growth. Research Design: Prospective study of children aged 12-60 months with FTT involving physical examination, parental survey, and polysomnography. Setting: Tertiary-care urban medical center. Subjects: 50 children aged 12-60 months without diagnosed syndrome or birth defect seen at the Boston Medical Center Grow clinic for FTT. Method: Participating children will have the following evaluations: 1. Physical examination of age, height, weight, z scores for weight, length/height, and weight for length (less than two years) or body mass index (over two years), tonsillar hypertrophy, and facial structure. 2. Pediatric sleep interview - the parents of participating children will be asked to complete a validated survey tool regarding symptoms relating to obstructive sleep disturbance. 3. Polysomnography - including EEG, EOG, EMG, pulse oximetry, end-tidal CO2, respiratory inductance plethysmography, ECG, and snoring amplitude. Data Analysis: The overall prevalence of OSD in children with FTT will be calculated. Additionally, the prevalence of OSD in subsets of children with FTT will be calculated stratifying for physical exam findings and results of the pediatric sleep questionnaire. Significance: There is reason to believe that OSD can cause or exacerbate FTT. There is good data to suggest that children with OSD and FTT who get treatment for the OSD have an improvement in their growth. If the prevalence of OSD is indeed significantly higher in children with FTT, then a large number of children with FTT will be evaluated and treated differently and may find rapid relief of their malady and improved growth.
Showing the most recent 10 out of 476 publications
