The long-term goal of this research is to determine the factors that mediate post-exercise hypotension and vasodilation. A single bout of aerobic exercise (e.g., cycling for 1 hour at a moderate level) produces a long-lasting decrease in blood pressure, known as """"""""post-exercise hypotension."""""""" It is believed that post-exercise hypotension may play a role in the beneficial anti-hypertensive effects of endurance exercise training. Conversely, exaggerated post-exercise hypotension may result in a detrimental tendency to faint after exercise. Thus, there is a need to further understand what mediates post-exercise hypotension. Currently it is unknown whether the endogenous vasodilator nitric oxide contributes to this phenomenon. The specific goal of this study is to determine the role of the nitric oxide in post-exercise hypotension and vasodilation. The study plan is based on a randomized crossover design used previously to investigate post-exercise hypotension (Halliwill et al. J Physiol Lond 495:279-288, 1996). After a familiarization session and fitness test, subjects will undergo parallel experiments on two separate days. The order of the experiments will be randomized between sham, a 60 min period of seated upright rest: and exercise, a 60 min period of seated upright cycling at 60% of their peak aerobic power. Exercise of this intensity and duration produces a sustained (~2 hr) post-exercise hypotension (Halliwill et al. Am J. Physiol. 270:R420-R426, 1996). Following both sham and exercise, subjects will receive, in sequence, systemic alpha-adrenergic blockade (phentolamine) and nitric oxide synthase blockade (L-NMMA). Before and after these interventions, systemic and regional hemodynamics will be measured.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
28
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Yu, Alan S L; Shen, Chengli; Landsittel, Douglas P et al. (2018) Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int 93:691-699
Kamimura, Daisuke; Suzuki, Takeki; Wang, Wanmei et al. (2018) Higher plasma leptin levels are associated with reduced left ventricular mass and left ventricular diastolic stiffness in black women: insights from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Hypertens Res 41:629-638
Nowak, Kristen L; You, Zhiying; Gitomer, Berenice et al. (2018) Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol 29:571-578
Tirumanisetty, P; Prichard, D; Fletcher, J G et al. (2018) Normal values for assessment of anal sphincter morphology, anorectal motion, and pelvic organ prolapse with MRI in healthy women. Neurogastroenterol Motil 30:e13314
McKenzie, Katelyn A; El Ters, Mirelle; Torres, Vicente E et al. (2018) Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: a retrospective analysis using the CRISP cohort. BMC Nephrol 19:378
Dad, Taimur; Abebe, Kaleab Z; Bae, K Ty et al. (2018) Longitudinal Assessment of Left Ventricular Mass in Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 3:619-624
Brosnahan, Godela M; Abebe, Kaleab Z; Rahbari-Oskoui, Frederic F et al. (2017) Effect of Statin Therapy on the Progression of Autosomal Dominant Polycystic Kidney Disease. A Secondary Analysis of the HALT PKD Trials. Curr Hypertens Rev 13:109-120
Kamimura, Daisuke; Suzuki, Takeki; Furniss, Anna L et al. (2017) Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness. J Cardiovasc Med (Hagerstown) 18:954-961
Chung, Jin Ook; Koutsari, Christina; Blachnio-Zabielska, Agnieszka U et al. (2017) Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans. Diabetes 66:2082-2091
West, Nancy A; Lirette, Seth T; Cannon, Victoria A et al. (2017) Adiposity, Change in Adiposity, and Cognitive Decline in Mid- and Late Life. J Am Geriatr Soc 65:1282-1288

Showing the most recent 10 out of 1267 publications