The combination of pyrazoloacridine and carboplatin is a potent and effective antitumor treatment.
The specific aims of this protocol are to define the maximum tolerated doses (MTD) of carboplatin (CBDCA) (30-minute infusion) and pyrazoloacridine (PZA) (3-hour infusion) without and with G-CSF, administered every 28 days, 2) to describe the toxicities of CBDCA and PZA given on the schedule described above, 3) to determine the effect of PZA on the intracellular retention of DNA-platinum adducts, 4) to relate the pharmacokinetics and metabolism of PZA to DNA-platinum adduct retention, 5) to seek preliminary evidence of therapeutic activity of the combination of CBDCA and PZA.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000585-29
Application #
6409634
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1976-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
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