Principle Investigator/Program Director (Last, fv'st, middle): Bumett, John, M.D.This competitive renewal application requests continuous funding (years 34-38) of the Mayo General ClinicalResearch Center. The GCRC integrates inpatient and outpatient activities at two distinct sites: the Saint MarysHospital unit (15,000 sq. ft.) has both inpatient and outpatient activity, and the Charlton Building outpatientGCRC (12,500 sq. R.) is exclusively for outpatients. The Charlton outpatient GCRC is an expansion of ourprogram since the previous grant renewal and was opened in 2000 to meet the increasing demand for outpatientstudies. In addition to the patient care areas, the GCRC has core laboratories, a metabolic kitchen,administrative offices, and conference rooms. A unique feature of the Mayo GCRC is the extensive corelaboratory facilities to perform detailed phenotyping, metabolic measurements, and body compositionmeasurements along with gastrointestinal, chemistry, exercise, sleep, microneurography, and echocardiographystudies. Since the previous site visit, these facilities have been substantially modernized and expanded to includethe addition of microarray and new mass spectrometers for proteomie measurements. We expanded the CDMASprogram to an Informatics and Bioinformaties core, which links various GCRC operations and data handling forGCRC investigators. The inpatient utilization (~80% by NIH grants, 95% A beds) remains stable at about 2,100beds; whereas, the outpatient utilization (-60% by NIH grants, 94% A visits) expanded more than three-fold to18,000 visits per year. There was a more than two-fold increase in NIH grants to 86 grants and more than 200protocols based in the GCRC. The major research activities are related to the following areas: 1) cancertherapies, 2) obesity and diabetes, 3) aging and hormonal secretion, 4) muscle, 5) osteoporosis, 6) vascularphysiology, 7) gastric physiology, 8) mechanisms of incontinence, 9) sleep disorders, 10) autonomic neuropathy,11) age-related valvular calcification, 12) hypertension, 13) vaccine research, and 14) neurodegenerativediseases. We have expanded education and training programs and outlined our vision for continued success ofGCRC as a resource for human research at Mayo.
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