Dysregulation of serotonergic neurotransmission has been linked to the cyclical, recurrent affective disorder known as Late Luteal Phase Dysphoric Disorder. This study proposes to probe the effect of central serotonergic depletion on mood by administering a diet and drink deficient in the 5-HT precursor, tryptophan, in an attempt to evoke dysphoric symptoms during the normally asymptomatic, follicular phase of the cycle.

Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
30
Fiscal Year
2002
Total Cost
$321,374
Indirect Cost
City
Dallas
State
TX
Country
United States
Zip Code
75390
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