This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In general, cystic fibrosis (CF) patients who are Hispanic have worse morbidity and mortality than Caucasian CF patients. However, the underlying mechanism(s) for this worsened status has not been elucidated. The purpose of the study/grant is to explore potential metabolic explanations for the worsened clinical status of Hispanic children with CF. The central hypothesis is that hyperglycemia occurs at a younger age in Hispanics with CF and that it is principally caused by underlying insulin resistance secondary to the Hispanic heredity. It is further hypothesized that insulin resistance includes hepatic insulin resistance and resistance to insulin's anti-catabolic effect which results in excessive amino acid substrate availability for gluconeogenesis.
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